Leilani Medel, 41, was a nurse in Bridgend, South Wales having immigrated from the Philippines.
Her death was reported on social media on Good Friday (April 10).
Her auntie Shiela Acheta wrote on Facebook: "In this distressing time, we express our love, concern, and condolences to the bereaved family of my niece, Leilani Medel, 41, from Bridgend, Wales, born in Divisoria, Santiago City, who passed away due to the COVID-19 pandemic.
"May her soul rest in peace.
"Please pray also for her husband and daughter in the UK who are still in the hospital fighting for their lives and fighting against COVID-19."
On March 19 Leilani changed her profile picture on Facebook to include the banner: #ICannotStayAtHome, I'mANurse.
It is not known when or where she contracted the deadly bug.
She is one of several Phillipino health workers who have died since the outbreak began including John Alagos, Donald Suelto, Amor Gatinao and Elbert Rico.